HAL (France)
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Efficient Plasma Cell Differentiation and Trafficking Require Cxcr4 Desensitization
CXCR4 plays a central role in B cell immune response, notably by promoting plasma cell (PC) migration and maintenance in the bone marrow (BM). Gain-of-function mutations in CXCR4 affecting receptor desensitization have been reported in the rare immunodeficiency called WHIM syndrome (WS). Despite lym
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