bioRxiv / medRxiv
open access
Metabolic outsourcing from ingested lactic acid bacteria extends Caenorhabditis elegans healthspan via bacterial amino acid and enzyme provision
Lactic acid bacteria promote longevity, yet the host-microbe metabolic mechanisms remain obscure. Using Caenorhabditis elegans, which lacks a urea cycle, we investigated how Lactococcus lactis JCM 5805 (Lc5805) extends lifespan. Live Lc5805 consumption upregulated 74 cuticle-formation genes, primari
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