bioRxiv / medRxiv
open access
Activated macrophages restrict invasive bacterial infection in a human intestinal organoid co-culture model
Intestinal organoids provide physiologically relevant models of the epithelial barrier, but lack the immune compartment that critically shapes host responses to infection. Here, we established a human colon organoid-derived monolayer co-culture system with macrophage-like THP-1 cells positioned dire
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