bioRxiv / medRxiv
open access
CC BY-NC-ND 4.0
Digital motor and cognitive variability as early markers of the prodromal Parkinsons disease spectrum
BackgroundIndividuals with isolated REM sleep behaviour disorder (iRBD) show motor and cognitive dysfunction prior to clinical -synucleinopathy. Performance instability may represent an earlier marker of neurodegeneration but remains underexplored using digital tests. ObjectivesTo assess baseline a
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