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Mutant IDH1 Expression Drives TERT Promoter Reactivation as Part of the Cellular Transformation Process

Ohba, Shigeo et al.
eScholarship · Papers
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Mutations in the isocitrate dehydrogenase gene IDH1 are common in low-grade glioma, where they result in the production of 2-hydroxyglutarate (2HG), disrupted patterns of histone methylation, and gliomagenesis. IDH1 mutations also cosegregate with mutations in the ATRX gene and the TERT promoter, su
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