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Sex disparate gut microbiome and metabolome perturbations precede disease progression in a mouse model of Rett syndrome

Neier, Kari et al.
eScholarship · Papers · License: CC BY
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31-biological-sciences-for-20203107-microbiology-for-2020
Rett syndrome (RTT) is a regressive neurodevelopmental disorder in girls, characterized by multisystem complications including gut dysbiosis and altered metabolism. While RTT is known to be caused by mutations in the X-linked gene MECP2, the intermediate molecular pathways of progressive disease phe
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