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Interleukin-1 Influences Ischemic Brain Damage in the Mouse Independently of the Interleukin-1 Type I Receptor
The cytokine interleukin-1β (IL-1β) contributes to ischemic, excitotoxic, and traumatic brain injury. IL-1β actions depend on interaction with a single receptor (IL-1RI), which associates with an accessory protein (IL-1RAcP), and is blocked by IL-1 receptor antagonist (IL-1ra). Here we show that in
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