HAL (France)
open access
Divalent cation depletion enhances intrinsic neuronal excitability through CaSR-dependent modulation of threshold ion channels
Abstract External calcium ([Ca2+]e) and magnesium ([Mg2+]e) concentrations fluctuate across physiological and pathological brain states. For example, [Ca2+]e decreases during intense neuronal activity and epilepsy, whereas it rises during sleep. Similarly, [Mg2+]e varies with the sleep/wake cycle an
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