HAL (France)
open access
Intracellular deposits of amyloid-beta influence the ability of human iPSC-derived astrocytes to support neuronal function
Abstract Background Astrocytes are crucial for maintaining brain homeostasis and synaptic function, but are also tightly connected to the pathogenesis of Alzheimer’s disease (AD). Our previous data demonstrate that astrocytes ingest large amounts of aggregated amyloid-beta (Aβ), but then store, rath
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