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Dock & design: engineering specificity for an alternative pimaradiene outcome with the ent-kaurene synthase from Bradyrhizobium japonicum

Schmidt-Dannert, Mark et al.
Iowa State University Digital Repository · Papers · License: CC BY-NC 4.0
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and-structural-biologybiochemistrybiophysicslife-sciences
The complexity of the reactions catalyzed by terpene synthases has hindered enzymatic engineering. In most cases such efforts result in non-specific product outcome, with the targeted compound being produced alongside others, hindering further use. Previous work with the structurally characterized e
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