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Hyper-mutational processes provide a head-start for weak cancer drivers: Explaining atypical <i>KRAS</i> variants

Michael D. Nicholson et al.
PLOS · Papers · License: CC BY 4.0
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colorectal-cancermutation
Hypermutant cancers frequently contain atypical driver gene variants, which may provide sub-optimal oncogenic advantages. The reason why weak cancer drivers prevail and are not outcompeted by stronger alternatives is unclear. Here, using mathematical modelling, we show that aberrant mutational proc
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