Structured-data reporting shapes the apparent causes of phase-3 trial failure: an automated decomposition of ClinicalTrials.gov records

Objective. To decompose the causes of phase-3 failure from ClinicalTrials.gov automatically, to identify where the registry misleads, and to compare the result with the manual study of Hwang et al. (2016). Methods. Cross-sectional study of registry records: every phase-3 registration with posted re