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Multiplex methylation marker analysis for ctDNA detection in liquid biopsies from anal cancer patients: an HPV-independent approach.
Anal squamous cell carcinoma (ASCC) is a rare gastrointestinal cancer linked to high-risk human papillomavirus (HPV) infection in approximately 90% of cases. Current circulating tumor DNA (ctDNA) approaches in ASCC primarily rely on pathogenic HPV-based biomarkers; however, these methods do not dete
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