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Synthesis of new anilinoquinazoline derivatives as potential anticancer agents: Antiproliferative activity, molecular docking and molecular dynamics studies

Abdul Wahab, Muhammad Kumayl
UM Research Repository · Papers · License: CC BY-NC-ND 4.0
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chemistrymaterials-chemistrymolecular-dockingmolecular-dynamicspharmacologysynthesis
Current reversible epidermal growth factor (EGFR) tyrosine kinase inhibitors of the non-small cell lung cancer (NSCLC) have been resisted by T790M mutation, while irreversible inhibitors introduced to overcome the mutation have faced resistance from C797S mutation. In the effort to discover potentia
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