bioRxiv / medRxiv
open access
Maternal high-fat diet drives sex-specific microglia remodeling of serotonergic reward circuitry
Maternal nutrition shapes offspring brain development and influences neurodevelopmental disorder risk, but the underlying mechanisms remain unclear. In mice, maternal high-fat diet exposure disrupted microglia-serotonin interactions during a critical postnatal period, producing persistent, sex-speci
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