bioRxiv / medRxiv
open access
Structures of MeCP2 bound to nucleosomes reveal distinct mechanisms of Rett syndrome mutations
Methyl-CpG binding protein 2 (MeCP2) is a chromatin-associated regulator essential for neuronal gene regulation, and pathogenic mutations in MeCP2 cause Rett syndrome (RTT). However, the mechanisms governing MeCP2 engagement on chromatin and the effects of RTT mutations on nucleosome interactions re
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