bioRxiv / medRxiv
open access
Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease
INTRODUCTIONCognitive decline in Parkinsons disease (PD) may reflect interacting neurodegenerative and cerebrovascular processes, but their distinct temporal contributions remain unclear. METHODSNewly diagnosed, untreated PD participants from the PPMI who were cognitively normal at baseline and had
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