Adhesion differentials control the rheology of biomimetic emulsions

[2503.18782] Adhesion differentials control the rheology of biomimetic emulsions Skip to main content Search Submit Donate Log in Search arXiv Press Enter to search · Advanced search Condensed Matter > Soft Condensed Matter arXiv:2503.18782 (cond-mat) [Submitted on 24 Mar 2025 ( v1 ), last revised 12 Sep 2025 (this version, v3)] Title: Adhesion differentials control the rheology of biomimetic emulsions Authors: Quentin Guigue , Marc Besse , Raphael Voituriez , Alexis M. Prevost , Elie Wandersman , Matthias Merkel , Lea-Laetitia Pontani View a PDF of the paper titled Adhesion differentials control the rheology of biomimetic emulsions, by Quentin Guigue and 6 other authors View PDF HTML (experimental) Abstract: Animal morphogenesis involves complex tissue deformation processes, which require tight control over tissue rheology. Yet, it remains insufficiently understood how tissue rheology results from the interplay between cellular packing and cellular forces, such as cortical tension, cell pressure, and cell-cell adhesion. Here, we follow a biomimetic approach to study this interplay. We mimic adhesive cells with oil droplets whose adhesion strength and specificity can be flexibly tuned. Using microfluidics, we expose 2D emulsions to an oscillatory geometry imposing cyclic pure shear, and we develop a geometric method to quantify their rheology using only imaging data. We find that some of the emulsions made of two droplet types progressively change their yielding behavior across subsequent shear cycles. Combining this with vertex model simulations, we show that the observed shift in yielding behavior is due to a progressive compaction, which only occurs in emulsions with a high adhesion differential and only when exposed to oscillatory shear. Gradients of cell compaction have been observed during animal development. Our work demonstrates how such gradients can be used to control gradients of tissue rheological properties. Moreover, the progressive compaction suggests the emergence of a pumping mechanism, which potentially acts in many cellular materials, from foams to tissues. Comments: 15 pages, 4 figures Subjects: Soft Condensed Matter (cond-mat.soft) Cite as: arXiv:2503.18782 [cond-mat.soft] (or arXiv:2503.18782v3 [cond-mat.soft] for this version) https://doi.org/10.48550/arXiv.2503.18782 Focus to learn more arXiv-issued DOI via DataCite Journal reference: Biophysical Journal 125 (2026) 1686 Related DOI : https://doi.org/10.1016/j.bpj.2026.03.004 Focus to learn more DOI(s) linking to related resources Submission history From: Matthias Merkel [ view email ] [v1] Mon, 24 Mar 2025 15:32:05 UTC (13,941 KB) [v2] Wed, 28 May 2025 12:48:29 UTC (12,247 KB) [v3] Fri, 12 Sep 2025 16:03:50 UTC (6,587 KB) Full-text links: Access Paper: View a PDF of the paper titled Adhesion differentials control the rheology of biomimetic emulsions, by Quentin Guigue and 6 other authors View PDF HTML (experimental) TeX Source view license Ancillary-file links: Ancillary files ( details ) : SI.pdf Current browse context: cond-mat.soft < prev | next > new | recent | 2025-03 Change to browse by: cond-mat References & Citations NASA ADS Google Scholar Semantic Scholar export BibTeX citation Loading... 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