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Overexpression of survival motor neuron improves neuromuscular function and motor neuron survival in mutant SOD1 mice

Turner, BJ et al.
The University of Melbourne Library Digital Repository · Papers
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amyotrophic-lateral-sclerosis
Spinal muscular atrophy results from diminished levels of survival motor neuron (SMN) protein in spinal motor neurons. Low levels of SMN also occur in models of amyotrophic lateral sclerosis (ALS) caused by mutant superoxide dismutase 1 (SOD1) and genetic reduction of SMN levels exacerbates the phen
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