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IGFBP3 promotes resistance to Olaparib via modulating EGFR signaling in advanced prostate cancer

Leslie, Amy R et al.
eScholarship · Papers · License: CC BY-NC-ND
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3202-clinical-sciences-for-2020
Olaparib is a pioneering PARP inhibitor (PARPi) approved for treating castration-resistant prostate cancer (CRPC) tumors harboring DNA repair defects, but clinical resistance has been documented. To study acquired resistance, we developed Olaparib-resistant (OlapR) cell lines through chronic Olapari
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