Livestock Contact and MRSA in Rural Areas

Background: \- MRSA is a type of bacteria that causes serious health problems. It can cause severe infections and is difficult to treat. MRSA has been found in a high number of people who work with some kinds of livestock, such as pigs. Researchers want to study people in rural areas, where more people work with or around livestock. They want to see if MRSA is more common or causes more serious infections in these areas. Objectives: \- To look at the relationship between livestock handling (especially pigs) and MRSA bacteria in people in rural areas. Eligibility: * Participants in the Agricultural Health Study in Iowa, including those who are exposed to livestock. * Healthy volunteers who are not exposed to livestock. Design: * This study requires an initial visit and monthly follow-up surveys for 18 months. * At the first visit, participants will have throat and nose swabs to collect cell and bacteria samples. They will also complete a questionnaire about their health habits. Other questions will ask about any work that brings them into contact with livestock like cows, pigs, or chickens. * Every month for the next 17 months, participants will complete another questionnaire to record any changes in their health and livestock contact information. They will also collect throat and nose swabs. They will send the questionnaires and the swabs to the study researchers. * Participants will be paid for the first visit and for every monthly survey and swab collection they return. * No treatment will be given as part of this protocol.