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Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

Azumaya, Caleigh M et al.
eScholarship · Papers
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Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble synthetic human variable heavy (VH) domains toward neutralizing epitopes. We constructed a VH-phage library and targeted the angioten
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