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Differential lipid signaling from CD4+ and CD8+ T cells contributes to type 1 diabetes development

White, Tayleur D et al.
eScholarship · Papers · License: CC BY
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Introduction: We reported that Ca2+-independent phospholipase A2β (iPLA2β)-derived lipids (iDLs) contribute to type 1 diabetes (T1D) onset. As CD4+ and CD8+ T cells are critical in promoting β-cell death, we tested the hypothesis that iDL signaling from these cells participates in T1D development. M
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