Reduced Ca2+ current, charge movement, and absence of Ca2+ transients in skeletal muscle deficient in dihydropyridine receptor beta 1 subunit

The Ca2+ currents, charge movements, and intracellular Ca2+ transients in mouse skeletal muscle cells homozygous for a null mutation in the cchbl gene encoding the 131 subunit of the dihydropyridine receptor have been characterized. /p3nul, the L-type Ca2+ current of mutant cells, had a -1 3-fold lo