HAL (France)
open access
Regulation of the Human Cyclin-dependent Kinase Inhibitor p18 by the Transcription Factors E2F1 and Sp1
The p18(INK4c) cyclin-dependent kinase inhibitor is an important regulator of cell cycle progression and cellular differentiation. We and others found that overexpressed E2F proteins up-regulate p18 expression. To better understand this phenomenon, we performed a functional analysis of the human p18
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