bioRxiv / medRxiv
open access
The obesity associated BDNF intron-3 cis-regulatory element, BE5.1, modulates the effects of early-life stress on weight gain, anxiety and gene expression in a sex dependent manner.
Early-life stress (ELS) has been associated with increases in obesity and anxiety and affects males and females in different ways. Animal and human studies indicate that ELS has maladaptive effects on brain development due, in part, to disruptions in the expression of genes that include brain-derive
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