bioRxiv / medRxiv
open access
A Proximity-Driven Functional Screening Platform for the Discovery of Noninhibitory USP7 Ligand Enabling Targeted Protein Stabilization
Targeted protein stabilization by deubiquitinase-targeting chimeras (DUBTACs) has emerged as a promising therapeutic strategy for preserving the function of essential proteins. DUBTACs are bifunctional molecules that recruit deubiquitinating enzymes (DUBs) to remove ubiquitin chains from substrate p
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