bioRxiv / medRxiv
open access
Ileal Gpbar1 gates depressive phenotypes via gut to brain "vagal-NTS-PVN"GABAergic axis
Depression represents a typical mental condition, yet whether intestinal metabolic signals drive central neural circuits remains unclear. Here we identify ileal enteric neuronal Gpbar1 as a previously unrecognized peripheral node that coordinates gut-to-brain communication to prevent depression-like
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