bioRxiv / medRxiv
open access
Matched marrow and blood profiling reveals compartment- and feature-specific liquid-biopsy signals in multiple myeloma
Multiple myeloma is bone-marrow-predominant, motivating marrow plasma cell-free DNA (cfDNA) as a tumor-proximal liquid biopsy. We tested whether marrow plasma cfDNA better represents the myeloma genome than peripheral blood cfDNA by profiling matched marrow plasma cells and both cfDNA compartments f
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