bioRxiv / medRxiv
open access
Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models
Many disease-associated variants are thought to act through gene regulation, yet conventional eQTL mapping explains only a fraction of GWAS loci, potentially because regulatory effects vary across cellular states and environments. We present CASTIE, a scalable Poisson mixed-model framework that dire
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