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Influenza Polymerase Can Adopt an Alternative Configuration Involving a Radical Repacking of PB2 Domains
Influenza virus polymerase transcribes or repli- cates the segmented RNA genome (vRNA) into respectively viral mRNA or full-length copies and ini- tiates RNA synthesis by binding the conserved 30 and 50 vRNA ends (the promoter). In recent structures of promoter-bound polymerase, the cap-binding and
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