HAL (France)
open access
Human Hematopoietic Reconstitution and HLA-Restricted Responses in Nonpermissive Alymphoid Mice
Abstract We generated a new humanized mouse model to study HLA-restricted immune responses. For this purpose, we created unique murine hosts by enforcing the expression of human SIRPα by murine phagocytes in murine MHC-deficient HLA-transgenic alymphoid hosts, an approach that allowed the immune rec
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