Alterations in resting-state functional connectivity of the salience network in patients with schizophrenia with and without cannabis use disorder comorbidity.

Schizophrenia (SCZ) is a mental disorder with as yet undefined aetiology and pathogenesis, with a prevalence of approximately 1%. About one in four individuals with SCZ is diagnosed with comorbid Cannabis Use Disorder (CUD) (1). The neural mechanisms linking cannabis use to worse prognosis in SCZ a