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QbD product development: rapid optimization and scale-up of PBAE-based siRNA delivery via DoE-guided microfluidics
Poly(β-amino ester) (PBAE)-based nanoparticles have emerged as promising carriers for RNA delivery, yet clear design rules linking formulation parameters to performance are still lacking. In this study, a Quality by Design (QbD)-guided and Design of Experiments (DoE)-driven approach was combined wit
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