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De Novo Discovery of Bicyclic Competitive Inhibitors of Zika Virus Protease from Peptide–Bismuth Phage Display Screening
No specific vaccines or therapeutics are currently available for the prevention or treatment of Zika virus infections. The viral protease NS2B-NS3 is essential for the replication of Zika and other orthoflaviviruses, making it a target for antiviral drug development. Traditional discovery of competi
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