The isoflavone metabolites, O-desmethylangolensin and (S)-equol, relax isolated arteries ex vivo and decrease arterial blood pressure in vivo

Dietary isoflavones are suggested to have positive cardiovascular effects. Their intestinal absorption is low, but they undergo extensive gastrointestinal metabolism by gut bacteria, resulting in metabolites with higher bioavailability. However, there is limited data on the effect of individual pure