HAL (France)
open access
A single nucleotide insertion prevents the in vivo response of the Hairless gene to thyroid hormone
The transcription of the Hairless gene (Hr), which encodes a histone demethylase, is strongly induced by thyroid hormone (T3) in many cell types. This is mediated by heterodimers formed between T3 nuclear receptors and retinoid X receptors. These heterodimers are bound to specific DNA response eleme
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