HAL (France)
open access
All screens lead to polo-like kinase 1: A central node in cancer therapeutics and resistance
A C T Polo-like kinase 1 (PLK1) is a mitotic kinase that is frequently overexpressed across many cancer types and strongly associated with poor prognosis and resistance to treatment. Comprehensive genomic, genetic, and pharmacological screens consistently pinpoint PLK1 as a therapeutic target
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