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Human cytomegalovirus exploits host chromatin remodeler MORC2 to promote the DNA damage response on viral genomes

Jiseok Jeong et al.
PLOS · Papers · License: CC BY
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chromatindna-repair
Human cytomegalovirus (HCMV) harbors a 230-kb double-stranded DNA genome whose replication induces extensive DNA damage during lytic infection. Because HCMV lacks canonical DNA repair machinery, it relies on host DNA damage response (DDR) pathways. However, the mechanisms that govern the preferenti
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