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Intranasal HSV‑1 infection drives region‑specific interferon‑dominant microglial remodeling

Seth Frietze et al.
PLOS · Papers · License: CC BY
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Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen capable of invading the central nervous system (CNS) and is associated with chronic neuroinflammation, cognitive impairment, and neurodegenerative disease. While microglia orchestrate the initial immune response to HSV‑1, the molecular m
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