bioRxiv / medRxiv
open access
Osmo-hydraulic volume regulation ensures robust endothelial-to-haematopoietic transition
Haematopoietic stem and progenitor cells (HSPCs) emerge from specialised haemogenic endothelial cells (HECs) in the ventral wall of the dorsal aorta (VDA) through a process known as endothelial-to-haematopoietic transition (EHT). During EHT, elongated HECs undergo actomyosin-driven rounding and extr
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