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A Phase I Study of [177Lu]Lu-FF58 in Patients With Advanced Solid Tumors.
advanced-solid-tumorsesophageal-cancergastric-adenocarcinomagastric-cancergbmglioblastoma-multiformepancreatic-cancerpancreatic-ductal-adenocarcinoma
The purpose of the study is to test the safety and dosing of \[177Lu\]Lu-FF58, a radioligand therapy for patients with advanced or metastatic tumors that express proteins known as integrins: alpha-v beta-3 integrin (αvβ3) and alpha-v beta-5 integrin (αvβ5). The study will also further characterize the radioligand imaging agent \[68Ga\]Ga-FF58 including its ability to identify tumor lesions and its safety profile.
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