Apoptosis: An Insight into Role in Health and Disease | Zenodo Skip to main Communities My dashboard Log in Sign up Published April 21, 2026 | Version v1 Journal article Open Apoptosis: An Insight into Role in Health and Disease Authors/Creators Austine-Okezie Ogechukwu Lucy Alphonsus Ogbonna Ogbuabor Silas Anayo Ufelle Dorathy Chizoba Onovo Description Abstract: Apoptosis is a tightly regulated form of programmed cell death essential for maintaining tissue homeostasis and normal development. It is characterized by distinct morphological and biochemical features, including cell shrinkage, chromatin condensation, DNA fragmentation, and membrane blebbing. Apoptosis occurs through two major pathways: the intrinsic (mitochondrial) and extrinsic (death receptor) pathways, both of which lead to the activation of caspases. The intrinsic pathway is triggered by internal stress signals such as DNA damage and oxidative stress, while the extrinsic pathway is initiated by ligand binding to cell surface death receptors. Physiologically, apoptosis is crucial for embryogenesis, immune regulation, and the removal of damaged or harmful cells. However, its dysregulation contributes to disease; reduced apoptosis can result in cancer, whereas excessive apoptosis is linked to neurodegenerative disorders and tissue injury. Due to its central role in disease, apoptosis represents an important therapeutic target in modern biomedical research. Keywords: Apoptosis, Mechanisms, Regulation, Physiology, Pathology, Diseases. Title: Apoptosis: An Insight into Role in Health and Disease Author: Austine-Okezie Ogechukwu Lucy., Alphonsus Ogbonna Ogbuabor, Silas Anayo Ufelle, Dorathy Chizoba Onovo International Journal of Recent Research in Life Sciences (IJRRLS) ISSN 2349-7823 Vol. 13, Issue 2, April 2026 - June 2026 Page No: 1-4 Paper Publications Website: www.paperpublications.org Published Date: 21-April-2026 DOI: https://doi.org/10.5281/zenodo.19680990 Paper Download Link (Source) https://www.paperpublications.org/upload/book/Apoptosis%20An%20Insight%20into%20Role%20in%20Health%20and%20Disease-21042026-7.pdf Files Apoptosis An Insight into Role in Health and Disease-21042026-7.pdf Files (566.5 kB) Name Size Download all Apoptosis An Insight into Role in Health and Disease-21042026-7.pdf md5:4f5a5e5cef726b66ce2c5e9887acf423 566.5 kB Preview Download Additional details Identifiers EISSN 2349-7823 URL https://www.paperpublications.org/upload/book/Apoptosis%20An%20Insight%20into%20Role%20in%20Health%20and%20Disease-21042026-7.pdf 19 Views 87 Downloads Show more details All versions This version Views Total views 19 19 Downloads Total downloads 87 87 Data volume Total data volume 51.0 MB 51.0 MB More info on how stats are collected.... Versions External resources Indexed in OpenAIRE Communities Keywords and subjects Keywords Apoptosis Mechanisms Regulation Physiology Diseases MeSH (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride Details DOI DOI Badge DOI 10.5281/zenodo.19680990 Markdown [](https://doi.org/10.5281/zenodo.19680990) reStructuredText .. image:: https://zenodo.org/badge/DOI/10.5281/zenodo.19680990.svg :target: https://doi.org/10.5281/zenodo.19680990 HTML <a href="https://doi.org/10.5281/zenodo.19680990"><img src="https://zenodo.org/badge/DOI/10.5281/zenodo.19680990.svg" alt="DOI"></a> Image URL https://zenodo.org/badge/DOI/10.5281/zenodo.19680990.svg Target URL https://doi.org/10.5281/zenodo.19680990 Resource type Journal article Publisher Paper Publications (www.paperpublications.org) Published in International Journal of Recent Research in Life Sciences (IJRRLS), 13(2), 1-4, ISSN: 2349-7823, 2026. Languages English Rights License Creative Commons Attribution 4.0 International The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited. Read more Citation Export Technical metadata Created April 25, 2026 Modified April 25, 2026 Jump up About About Policies Infrastructure Principles Projects Roadmap Contact Blog Blog Support Help FAQ Developers REST API OAI-PMH Contribute GitHub Donate Funded by Powered by CERN Data Centre & InvenioRDM Status Privacy policy Cookie policy Terms of Use This site uses cookies. Find out more on how we use cookies Accept all cookies Accept only essential cookies