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Yeast pericentrin/Spc110 contains multiple domains required for tethering the γ-tubulin complex to the centrosome
The Saccharomyces cerevisiae spindle pole body (SPB) serves as the sole microtubule-organizing center of the cell, nucleating both cytoplasmic and nuclear microtubules. Yeast pericentrin, Spc110, binds to and activates the γ-tubulin complex via its N terminus, allowing nuclear microtubule polymeriza
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