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Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina
Balancing the competing demands of phagolysosomal degradation and autophagy is a significant challenge for phagocytic tissues. Yet how this plasticity is accomplished in health and disease is poorly understood. In the retina, circadian phagocytosis and degradation of photoreceptor outer segments by
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