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Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease
BackgroundThe APOE ε4 allele is the most significant common genetic risk factor for late-onset Alzheimer’s disease (LOAD). The region surrounding APOE on chromosome 19 has also shown consistent association with LOAD. However, no common variants in the region remain significant after adjusting for AP
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