bioRxiv / medRxiv
open access
Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants
The alarming rise in antimicrobial resistance reinforces an urgent need for new antimicrobial strategies. Host- or bacteria-derived chemicals, such as polyamines, present at infection sites often influence microbial virulence and antibiotic response. Polyamines are cationic small molecules overprodu
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