bioRxiv / medRxiv
open access
Therapeutic blockade of IL-1β in PWH reduced the HIV reservoir via mechanisms of enhanced CD8 and CD4 effector function and reversal of monocyte dysfunction
Chronic IL-1{beta}-driven inflammation contributes to cardiovascular risk and potentially HIV reservoir persistence in people with HIV (PWH); the effects of direct IL-1{beta} blockade on HIV persistence have not been defined. We show in a cohort of PWH that canakinumab, an anti-IL-1{beta} monoclonal
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