Impact of Advanced Platelet Rich Fibrin and Enamel Matrix Derivative on Clinical and Molecular Wound Healing Parameters After Surgical Removal of Mandibular Third Molars

Brief summary The goal of this study is to compare the effects of advanced platelet rich fibrin and enamel matrix derivative placed in the extraction alveoli of patients who had surgical removal of mandibular wisdom teeth. The questions it aims to answer/evaluate are: * postoperative pain, swelling, trismus, early wound healing using soft tissue healing index * level of early local inflammatory response by measuring levels of inflammatory mediators in wound exudate * degree of wound healing by measuring levels of early wound healing mediators in wound exudate * incidence of alveolar osteitis and delayed infection * levels of probing depth, clinical attachment loss, gingival margin level, bleeding on probing, gingival index, plaque index of the second mandibular molar 3 months after surgery Participants of the study will be asked: * for their preoperative clinical measurements (swelling, trismus, periodontal parameters) to be taken by the principal investigator * to provide 20 ml of venous blood if necessary * to preoperatively provide gingival crevicular fluid in the region of distal surface of the second mandibular molar and postoperatively wound exudate * to note the number of painkiller pills taken after surgery and pain levels in different time points * to come to regular checkups in which clinical measuring of postoperative swelling, trismus levels and periodontal parameters will be performed