Directional Pressure Failure: Alignment, Signal Accuracy, and Incomplete Physiological Resolution, LoS, Resolution Failure, v13, April 2026 | Zenodo Skip to main Communities My dashboard Log in Sign up Published April 23, 2026 | Version 13 Preprint Open Directional Pressure Failure: Alignment, Signal Accuracy, and Incomplete Physiological Resolution, LoS, Resolution Failure, v13, April 2026 Authors/Creators Martell, Beth Ann (Researcher) 1 Show affiliations 1. Southern Illinois University Carbondale Description This paper presents a systems-level formulation of Directional Pressure Failure (DPF), a physiological state in which fluid distribution, pressure gradients, and regulatory signaling become misaligned, resulting in continued system activity without completion of fluid redistribution or metabolic and acid–base resolution. Physiological regulation depends on alignment between physical conditions and the signals used to interpret them. On Earth, gravity organizes fluid distribution and pressure gradients, allowing baroreflex, hormonal, and renal systems to coordinate responses that converge toward equilibrium. In microgravity, the absence of gravitational direction alters fluid distribution and gradient structure. Pressure sensing mechanisms remain intact, but operate under changed physical conditions, producing responses that are internally consistent yet insufficient to fully resolve cardiovascular and fluid transitions. A parallel pattern is observed in hyperchloremic states associated with non–anion gap metabolic acidosis, where electrolyte and acid–base changes reflect regulatory output rather than restoration of equilibrium. In these cases, renal and hormonal systems execute signals appropriately, but those signals are mismatched to physiological conditions, resulting in persistent imbalance despite preserved organ function. This paper defines Directional Pressure Failure as a state of misalignment between physical conditions and regulatory signaling, in which physiological regulation persists but fails to converge to resolution. A mechanistic layer is introduced linking fluid distribution, compartmental hydration, electrolyte shifts (chloride and bicarbonate), and regulatory signaling (including RAAS and vasopressin), demonstrating how self-consistent but unresolved system states can emerge across both environmental and clinical contexts. This paper complements prior work describing the expression of DPF across microgravity and clinical states by developing the underlying systems model of alignment, signaling, and resolution. Notes This work extends the Lantern of Sulfur (LoS) framework by defining a shared failure pattern across microgravity and hyperchloremic physiology, linking directional pressure, regulatory signaling, and system state. For the complete Lantern of Sulfur framework, reading order, and updated convergence dynamics materials, see the Lantern of Sulfur Master Index (Concept DOI): https://doi.org/10.5281/zenodo.17915492 Version History v13 — Finalized sequence defining failure, constraint, recovery, and misinterpretation within a unified pressure–flow model v12 — Structural and conceptual development across LoS and Directional Pressure Failure (DPF) frameworks v11 and earlier — Iterative development of pattern recognition and system mapping Technical info (English) In microgravity, gravitational direction is removed, altering fluid distribution across compartments and disrupting pressure gradients that normally guide cardiovascular and renal regulation. Pressure sensing mechanisms remain intact, but operate within a modified physical environment. As a result, regulatory responses are internally consistent yet insufficient to restore whole-system equilibrium. This produces a state in which regulatory activity persists, but physiological convergence does not complete, contributing to incomplete cardiovascular adaptation and orthostatic intolerance upon return to gravity. Notes Rights / Provenance and Scope Note This record is part of the Lantern of Sulfur / Restoration Atlas provenance corpus . This module presents a conceptual systems component within the Lantern of Sulfur / Restoration Atlas corpus. Public access is provided for citation, review, scholarly discussion, and provenance verification. This work may not be used to extract, sequence, combine, operationalize, translate, or adapt the corpus into derivative frameworks, diagnostic tools, prompt systems, commercial products, datasets, training materials, applied methods, decision systems, analytic instruments, AI systems, or related systems without written permission from the author. This module is not an operational manual, diagnostic instrument, clinical protocol, software specification, prompt template, or authorization to reconstruct the Restoration Atlas method. It is a hypothesis-generating conceptual systems model intended to support interpretation, research discussion, and pattern recognition. License: Creative Commons Attribution–NonCommercial–NoDerivatives 4.0 International Short form: CC BY-NC-ND 4.0 Files DPF Alignment, Signal Accuracy, and Incomplete Physiological Resolution, LoS, Resolution Failure, v13, April 2026.pdf Files (383.9 kB) Name Size Download all DPF Alignment, Signal Accuracy, and Incomplete Physiological Resolution, LoS, Resolution Failure, v13, April 2026.pdf md5:626925fe6dfc317a4d6bc3060fc2832f 383.9 kB Preview Download Additional details Related works Is part of Preprint: 10.5281/zenodo.17915492 (DOI) Preprint: 10.5281/zenodo.17214027 (DOI) Is supplement to Preprint: 10.5281/zenodo.19362551 (DOI) Preprint: 10.5281/zenodo.19616353 (DOI) Preprint: 10.5281/zenodo.19670065 (DOI) Preprint: 10.5281/zenodo.19672640 (DOI) Preprint: 10.5281/zenodo.19672853 (DOI) Preprint: 10.5281/zenodo.19688202 (DOI) Preprint: 10.5281/zenodo.19713705 (DOI) Preprint: 10.5281/zenodo.19748264 (DOI) Dates Available 2026-04-20 First Release of Directional Control Failure in Microgravity A Systems Model of Fluid Misdistribution, Temporal Compensation, and Re-entry Instability (A–D Framework), LoS, Resolution Failure Series, v. 13, April 2026 Available 2026-04-20 First Release of Timing as Artificial Gravity: Temporal Sequencing as a Control System for Fluid Distribution Under Conditions of Directional Loss, LoS, Resolution Failure Series, v. 13, April 2026 Available 2026-04-20 First Release of Re-entry as Re-synchronization: Phase Dynamics of Physiological Recovery Following Directional Control Restoration, LoS, Resolution Failure Series, v. 13, April 2026 Available 2026-04-21 First Release of Directional Pressure Failure: A Shared Failure Pattern in Microgravity and Hyperchloremic States, LoS, Resolution Failure Series, v. 13, April 2026 Available 2026-04-23 First Release of Directional Pressure Failure: Alignment, Signal Accuracy, and Incomplete Physiological Resolution, LoS, Resolution Failure, v13, April 2026 269 Views 146 Downloads Show more details All versions This version Views Total views 269 54 Downloads Total downloads 146 47 Data volume Total data volume 82.9 MB 26.1 MB More info on how stats are collected.... 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